New antibiotic napyradiomycins A2 and B4 and stereochemistry of napyradiomycins.
- 1 January 1987
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 40 (9) , 1213-1219
- https://doi.org/10.7164/antibiotics.40.1213
Abstract
Napyradiomycins A2 and B4, new members of the napyradiomycins, have been isolated from the culture broth of Chainia rubra MG802-AF1. The structure of napyradiomycin A2 was elucidated as 16-hydroxy-17-methylenenapyradiomycin A1 by NMR studies. The absolute structure of napyradiomycin B4 was determined as 13-hydroxy-13-methylnapyradiomycin B1 by X-ray crystallography and therefore the configuration of C(4a) in other napyradiomycins is assumed as the R configuration. The geometrical isomerism of napyradiomycin C1 was estimated as 12E and 16E by nuclear Overhauser effect experiments.This publication has 2 references indexed in Scilit:
- Structures of new antibiotics napyradiomycins.The Journal of Antibiotics, 1986
- Novel antibiotics napyradiomycins. Production, isolation, physico-chemical properties and biological activity.The Journal of Antibiotics, 1986