INTERACTION PROPERTIES OF SONICALLY FRAGMENTED COLLAGEN MACROMOLECULES

Abstract
Sonic irradiation of soluble collagen (tropo-collagen, TC) involves scission at well-defined loci, identifiably by analysis of the band patterns of segment long-spacing (SLS) type aggregates. A heterogeneous population of macromolecules is produced whose diversity resides not only in particle length but also in end-to-end polymerization properties. The effects of sonic irradiation on TC solutions are best considered in terms of the occurrence of several different processes proceeding concurrently but at different rates, the most rapid being the impairment of the capacity of the irradiated solutions to form fibrils of native type (700 A repeat).

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