A Study of the Gastro-Secretagogue Power of Urine (P.S.U.) before and after Portacaval Anastomosis in Man

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Abstract
The gastric secretagogue effect of urine (‘pouvoir secretagogue urinaire’, P.S.U. test) from 20 patients who had been operated on with portacaval anastomosis (P.C.A.) for hepatic cirrhosis was examined before and after operation. Before operation, the urine from 4 subjects had a secretagogue effect, whereas after operation 19 patients produced an urine which increased the gastric secretion in the rat. The test was significantly different in the same group of patients before and after P.C.A. (p < 0.0001), and when we compared the group of postoperative patients and a group of 30 control cirrhotic patients (p < 0.001). The substance responsible for this urinary gastrosecretagogue power, appearing after portacaval anastomosis, is not histamine. Preliminary results seem to suggest that this substance is similar to that obtained in the Zollinger-Ellison syndrome.

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