Gastric Secretion and Free Histamine in Urine

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Abstract
Simultaneous determinations of the hourly outputs of free histamine in the urine and free acid in the juice from Heidenhain gastric pouches were made in dogs after the ingestion of meat. The gastric secretory response to the meal was separated into intestinal and gastric components. The rough parallelism, noted by others, between the outputs of acid in the gastric juice and free histamine in the urine after the meal was verified. When the meat was placed in the jejunum the output of histamine in the urine promptly increased while the output of acid was minimal or absent. Later, the output of acid increased while the output of histamine declined. Meat placed in the isolated stomach produced active secretion of acid but no increase in urinary histamine. No increase of urinary histamine followed a meal of bread and milk. During nervous secretion induced by insulin hypoglycemia, the output of free histamine in the urine did not change.

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