Trophic Effects of Somatostatin on Calcium Flux: Dynamic Analysis and Correlation with Pituitary Hormone Release*
- 1 October 1986
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 119 (4) , 1703-1707
- https://doi.org/10.1210/endo-119-4-1703
Abstract
Somatostatin (SRIF) modulates many aspects of normal physiology, appears useful as a potent antineoplastic agent, and may influence the development of degenerative brain disorders such as Alzheimer''s disease. Regulation of cellular calcium flux by SRIF may contribute greatly to many of these interactions, yet remains controversial, SRIF rapidly causes a sustained inhibition of fractional calcium efflux from prelabeled dispersed rat pituitary cells (IC50, .apprx. 40 pM) and evokes a large rebound increase in efflux after the infusion, each coinciding temporally with expected physiological effects on GH release. These data support a particular role for SRIF-regulated calcium flux in the normal pulsatile pattern of GH secretion and a more general role in the varied biological actions of the peptide.This publication has 22 references indexed in Scilit:
- Computer simulation and interpretation of45Ca efflux profile patternsThe Journal of Membrane Biology, 1982
- A Model System for the Study of Luteinizing Hormone (LH) Secretion: Lack of Effect of Fetal Calf Serum on Gonadotropin-Releasing Hormone Stimulated LH ReleaseExperimental Biology and Medicine, 1982
- Pulsatile Somatostatin Release from the Median Eminence of the Unanesthetized Rat and Its Relationship to Plasnia Growth Hormone Levels*Endocrinology, 1981
- Release of Growth Hormone from Purified Somatotrophs: Use of High K+and the Ionophore A23187 to Elucidate Interrelations among Ca++, Adenosine 3′,5′-Monophosphate, and Somatostatin*Endocrinology, 1981
- Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementaNature, 1980
- Inhibition of the acetylcholine-induced secretion of bovine growth hormone by somatostatinMolecular and Cellular Endocrinology, 1979
- Effects of somatostatin and verapamil on growth hormone release and 45Ca fluxesMolecular and Cellular Endocrinology, 1978
- Somatostatin- and Epinephrine-Induced Modifications of 45Ca++ Fluxes and Insulin Release in Rat Pancreatic Islets Maintained in Tissue CultureJournal of Clinical Investigation, 1977
- Somatostatin: Its inhibiting effect on the release of hormones and IgG from clonal cells strains its Ca-influx dependenceBiochemical and Biophysical Research Communications, 1977
- Inhibition of Calcium Uptake by Somatostatin in Isolated Rat Islets of LangerhansEndocrinology, 1976