Oxygen consumption during cimetidine and prostaglandin E2 inhibition of acid secretion.

Publisher Website
Google Scholar
Abstract
O2 consumption was determined during cimetidine and 16,16-dimethyl prostaglandin E2 inhibition of acid secretion in exteriorized segments of the greater curvature of dog stomach. Steady-state acid secretion during histamine infusion correlated well with O2 consumption (r = 0.85, P < 0.01). Cimetidine and 16,16-dimethyl prostaglandin E2 inhibition of acid secretion produced a reduction of O2 consumption to resting levels. In contrast, O2 consumption did not decrease appreciably during thiocyanate inhibition of acid secretion. Apparently the inhibition action of cimetidine and 16,16-dimethyl prostaglandin E2 precedes, whereas that of thiocyanate is at a point beyond the transfer of energy to the process of acid production.

This publication has 11 references indexed in Scilit: