Interaction Between Nonsteroidal Anti-Inflammatory Drugs and High-Dose Methotrexate: A Literature Review
- 1 January 1990
- journal article
- review article
- Published by SAGE Publications in Journal of Pediatric Oncology Nursing
- Vol. 7 (1) , 14-16
- https://doi.org/10.1177/104345429000700105
Abstract
An important step in preventing methotrexate (MTX) toxicity is to assess patient self-medication of over-the-counter drugs before high-dose methotrexate (HDMTX) treatment is administered. Nonsteroidal anti-inflammatory drugs given within a 10-day period before a patient receives HDMTX leads to a decreased MTX excretion rate causing MTX toxicity. Education of the nursing staff and patients and their families is vital to avoid the potentially dangerous effects of a delayed MTX excretion rate.Keywords
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