Toxic Effects of Aflatoxin B 1 in Chickens Given Feed Contaminated with Aspergillus flavus and Reduction of the Toxicity by Activated Charcoal and Some Chemical Agents
- 1 January 1984
- journal article
- research article
- Published by JSTOR in Avian Diseases
- Vol. 28 (1) , 61-69
- https://doi.org/10.2307/1590128
Abstract
A. flavus NRRL 3357 was grown on enriched long-grain rice for 7-10 days to produce aflatoxin B1 (AFB1). The quantitity of AFB1 in moldy rice was determined by thin-layer chromatography, using UV light. When the dried moldy rice powder was fed to day-old Hubbard .times. Hubbard broiler chicks in unmedicated feed (AFB1 level 10 ppm) for 8 wk, there was a profound reduction in weight gain and feed consumption. Chickens fed AFB1 developed severe liver damage, as determined by the concentration of hepatic microsomal cytochrome P-450, and by the activities of microsomal benzphetamine N-demethylase and serum glutamic oxalacetic transaminase. Activated charcoal, reduced glutathione, cysteine, S (as sodium selenite), .beta.-carotene, and fisetin administered orally considerably reduced the toxicity of AFB1 in the experimental chickens.This publication has 6 references indexed in Scilit:
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