Vascular Endothelial Growth Factors and Progression of Periodontal Diseases

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Abstract
Background: Tissues become hemorrhagic and edematous coincident to periodontal diseases; however, there is little information concerning the biologic mechanisms which may produce these changes. Vascular endothelial growth factor (VEGF) is a macromolecule which enhances blood vessel growth and permeability. However, there is no information concerning gingival VEGF concentrations within normal or diseased gingiva. The purpose of this study was to assess changes in gingival concentrations of VEGF during initiation and progression of periodontal diseases and compare them to changes in the number of blood vessel profiles and concentration of recognized markers of periodontal disease severity (interleukin‐6[IL‐6]).Methods: Normal (non‐hemorrhagic gingiva adjacent to a ≤3 mm gingival sulcus) and inflamed gingiva (hemorrhagic gingiva adjacent to a ≤3 mm, 4 to 6 mm, or >6 mm periodontal pocket) were studied. VEGF and IL‐6 concentrations were assessed by ELlSA and the number of blood vessels determined by histomorphometric techniques. Data were placed into one of the following groups: ≤3 mm, normal; ≤3 mm, diseased; 4 to 6 mm, diseased; and >6 mm, diseased. These groups were compared by factorial ANOVA and Scheffé comparisons. In addition, groups were compared by simple and multiple regression and regression ANOVA to determine possible correlations between them.Results: VEGF and IL‐6 concentrations were significantly lower within normal than within diseased gingiva. The number of blood vessel profiles and mean IL‐6 concentrations were highest in diseased tissues adjacent to >6 mm sulci and were significantly correlated with sulcular depth (P P Conclusions: VEGF may be a factor in initiation and progression of gingivitis to periodontitis, possibly by promoting expansion of the vascular network coincident to progression of the inflammation. J Periodonto1 1999; 70:848‐852.