microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma
Top Cited Papers
- 15 May 2008
- journal article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 68 (10) , 3566-3572
- https://doi.org/10.1158/0008-5472.can-07-6639
Abstract
MicroRNAs are noncoding RNAs inhibiting expression of numerous target genes, and a few have been shown to act as oncogenes or tumor suppressors. We show that microRNA-7 (miR-7) is a potential tumor suppressor in glioblastoma targeting critical cancer pathways. miR-7 potently suppressed epidermal growth factor receptor expression, and furthermore it independently inhibited the Akt pathway via targeting upstream regulators. miR-7 expression was down-regulated in glioblastoma versus surrounding brain, with a mechanism involving impaired processing. Importantly, transfection with miR-7 decreased viability and invasiveness of primary glioblastoma lines. This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma. [Cancer Res 2008;68(10):3566–71]Keywords
This publication has 19 references indexed in Scilit:
- Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5′ UTR as in the 3′ UTRProceedings of the National Academy of Sciences, 2007
- Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell linesCancer Cell, 2006
- A microRNA Mediates EGF Receptor Signaling and Promotes Photoreceptor Differentiation in the Drosophila EyeCell, 2005
- miR-15 and miR-16 induce apoptosis by targeting BCL2Proceedings of the National Academy of Sciences, 2005
- Extensive modulation of a set of microRNAs in primary glioblastomaBiochemical and Biophysical Research Communications, 2005
- Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAsGenes & Development, 2005
- Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiformeNeuro-Oncology, 2005
- RAS Is Regulated by the let-7 MicroRNA FamilyPublished by Elsevier ,2005
- MicroRNA-Directed Cleavage of HOXB8 mRNAScience, 2004
- Micro RNAs are complementary to 3′ UTR sequence motifs that mediate negative post-transcriptional regulationNature Genetics, 2002