Computational analysis of biological functions and pathways collectively targeted by co-expressed microRNAs in cancer
Open Access
- 1 November 2007
- journal article
- Published by Springer Nature in BMC Bioinformatics
- Vol. 8 (S7) , S16
- https://doi.org/10.1186/1471-2105-8-s7-s16
Abstract
Multiple recent studies have found aberrant expression profiles of microRNAome in human cancers. While several target genes have been experimentally identified for some microRNAs in various tumors, the global pattern of cellular functions and pathways affected by co-expressed microRNAs in cancer remains elusive. The goal of this study was to develop a computational approach to global analysis of the major biological processes and signaling pathways that are most likely to be affected collectively by co-expressed microRNAs in cancer cells.Keywords
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