Lack of Conformity in the Behaviour of Platelets during Normal Storage Conditions at 22°C

Publisher Website
Google Scholar
Abstract
Human platelets prepared from citrate-phosphate-dextrose blood under normal routine conditions and concentrated to 1000-1600.cntdot.109.cntdot.1-1 varied considerably in their capacity to acidify the medium. Serotonin uptake was well maintained for 5 days provided that ATP was within 50% of normal and pH was above 6.0. A strong release of platelet factor 4 was occasionally seen in relation to preparation. In some preparations the platelet factor 4 was well maintained for 5 days, in others a sudden or gradual release was seen during storage. Differences in the quality of routinely prepared platelets apparently occur during preparation and storage which are insufficiently well explained and controlled.