Multiplicity of Cell Response to the BAI Strain A (Myeloblastosis) Avian Tumor Virus. II. Nephroblastoma (Wilms' Tumor): Ultrastructure2

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Abstract
The ultrastructural features of the cells comprising the nephronic, mesenchymal, and chondral tissues of the avian nephroblastoma induced by the BAI strain A (myeloblastosis virus) have been studied. The findings support the interpretations of histologic examinations that the tumor arises by a series of parallel and discontinuous processes of growth and differentiation of primitive nephrogenic cells residual in the postembryonic kidney. No evidence was seen of genetic transformation; instead, particularly with the nephronic elements, differentiation was a manifestation of potentials inherent in the cells of origin. Virus and processes of virus synthesis were found in association with the cellular elements of all component tissues of the tumor. Virus elaboration and release from all cell types occurred alike, but in different degrees, by the budding of the cytoplasmic membrane. In the cartilage were virus particles apparently containing fibrils formed simultaneously by the membrane of the chondrocytes.

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