Structure-activity studies of some oleanane triterpenoid glycosides and their related compounds from the leaves of Tetrapanax papyriferum on anti-inflam-matory activities.

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Abstract
The antiinflammatory activities of oleanane triterpenoid glycosides, papyrioside L-IIa, L-IIb, L-IIc and L-IId, extracted from T. papyriferum (Araliaceae) and their aglycones, papyriogenin A and C and propapyriogenin A1 and A2, were investigated by using the carrageenan-induced edema and the cotton pellet granuloma tests in mice. Papyriogenin A and C (30 mg/kg p.o. [per os]) manifested in these tests almost the same potency as prednisolone (25 mg/kg p.o.). The structure-activity relationships of these and related triterpenes were investigated. This takes into account particularly variation in the O2 function and the molecular conformation. The anti-inflammatory activity of these triterpenes was favored when the molecules had a planar conformation; this was induced by the heteroanulardiene group between C and D ring.

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