Anti-inflammatory testing methods: Comparative evaluation of mice and rats.

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Abstract
The possibility of using mice in place of rats in antiinflammatory screening tests was investigated. The diversities of the responses between mice and rats on screening tests, that is, carrageenin, formalin-induced edema in the hind paw, adjuvant arthritis and cotton pellet granuloma were observed with p.o. [oral] administration of prednisolone, 0.5 and 5.0 mg/kg, and indomethacin, 0.5 and 5.0 mg/kg. On the effects of these drugs on screening tests, a similar type of phenomenon between rats and mice was found. The dose-response relationships of aspirin, flufenamic acid, phenylbutazone, cyproheptadine, prednisolone and indomethacin were examined in 4 kinds of screening tests mentioned above. Prednisolone, indomethacin, phenylbutazone and aspirin apparently inhibited the carrageenin, formalin-induced edema, cotton pellet granuloma and adjuvant arthritis, but flufenamic acid showed no inhibition of the carrageenin and formalin-induced edema. Cyproheptadine inhibited the formalin and serotonin-induced edema.