Synthesis, conformational flexibility and preliminary complexation behaviour of α,α′-trehalose-based macrocycles containing thiourea spacers

Publisher Website
Google Scholar
Abstract
An efficient synthesis of macrocyclic ligands incorporating two α,α′-trehalose subunits linked through the primary C-6,6′ positions by means of 1,3-thiourea spacers is reported; the Z/E configuration of the N–C(S) bonds is governed by intramolecular hydrogen bonding as well as steric factors.