Vaccination Against 77 Capsular Types of Klebsiella Aerogenes with Polyvalent Klebsiella Vaccines
- 1 December 1984
- journal article
- research article
- Published by Microbiology Society in Journal of Medical Microbiology
- Vol. 18 (3) , 413-421
- https://doi.org/10.1099/00222615-18-3-413
Abstract
A method is described for producing monovalent and polyvalent vaccines from culture filtrates of K. aerogenes. With a single injection, each monovalent vaccine protected mice against lethal i.p. challenge by > 30 capsular types; polyvalent vaccines containing 2-12 monovalent components protected against 46-61 of the 77 capsular types of K. aerogenes. One vaccine with 12 components, administered in 2 doses, induced full protection against 71 types and protected half of the mice challenged with the other 6 types.This publication has 14 references indexed in Scilit:
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