The Diverse Effects of Iodide on Thyroid Function

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Abstract
The extraordinarily diverse effects of iodide on thyroid hormone formation and secretion have interested and puzzled both clinicians and basic scientists for years, Iodide is an unusual substance in that its intake, in quantities in the order of 50 to 500 μg daily, is clearly essential for normal thyroid hormone formation and secretion. On the other hand, iodide has been shown to have multiple antithyroid actions. The anti-thyroid actions of iodide include inhibition of iodide organification, thus reducing thyroid hormone synthesis, and inhibition of release of stored thyroid hormone, which results in diminished thyroid hormone secretion and reduced plasma thyroid . . .