Congenital Goitrous Cretinism Due to the Absence of Iodide-Concentrating Ability

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Abstract
An 8-year-old goitrous cretin is presented whose thyroid, salivary glands, gastric mucosa and probably the choroid plexus have lost the ability for active transport of iodide. Treatment with iodide alone corrected the hypothyroidism. Five mg of I−/day gave partial and 14 mg I−/day gave complete return to the euthyroid state as shown in such indices as oxygen consumption, serum thyroxine, cholesterol and alkaline phosphatase levels, and urinary hydroxyproline excretion. Very large doses of I− (up to 803 mg/day) caused no further effects. Certain factors related to the nature of the tissue defect are briefly discussed.