Alcoholic liver injury: Defenestration in noncirrhotic livers—a scanning electron microscopic study
Open Access
- 1 January 1987
- journal article
- research article
- Published by Wolters Kluwer Health in Hepatology
- Vol. 7 (1) , 77-82
- https://doi.org/10.1002/hep.1840070117
Abstract
The fenestration of hepatic sinusoidal endothelial cells in 15 needle biopsies obtained from chronic alcoholics without cirrhosis was studied by scanning electron microscopy. As compared to nonalcoholics, a significant reduction in the number of fenestrae and porosity of the sinusoidal lining wall (fractional area of fenestrae) was observed in acinar Zone 3, both in biopsies with and without Zone 3 fibrosis as judged by light microscopy. A significant reduction of porosity as shown in this study may influence the blood hepatocytic exchange and contribute to the alcohol-induced liver injury.Keywords
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