Antimicrobial-susceptibility testing of rapidly growing pathogenic bacteria

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Abstract
The Comparative, Stokes, Ericsson, and Kirby-Bauer methods for antimicrobial-susceptibility testing were compared in a field trial in 36 laboratories; each method was used in nine laboratories. With many of the organisms and antimicrobial agents, intra-laboratory variation in zone size was least in tests by the Kirby-Bauer method, but in corresponding inter-laboratory comparisons no one method had a marked advantage over the others. Variation in zone sizes led to some major variations in the interpretation of results. With organisms other than pseudomonads, this occurred more often in tests by the Ericsson method; and with pseudomonads more often by the Ericsson and the Kirby-Bauer methods than by the other methods. In 8.1% of all combinations of bacterial strain and antimicrobial agent examined, there were major discrepancies between the modal interpretations of results obtained by different methods.

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