Clearance of Compounds of Different Molecular Size in the Human Placenta in vitro

Publisher Website
Google Scholar
Abstract
The placental clearance of selected water-soluble molecules and antipyrine was evaluated using a dual perfusion of human placental lobules in vitro. When graded according to decreasing clearance, the sequence of the molecules was as follows: water = antipyrine > urea > p-aminohippuric acid > inulin > dextran 20 > dextran 70. A close correlation was obtained between the clearance and the free diffusion coefficient of these molecules. However, no restricted diffusion was observed in the molecular range studied. These results suggest an equivalent pore size larger than 90 Å for the human placental membrane in vitro.