Inhibition of Growth of Mycobacterium Tuberculosis by a Mold Product—the Effect on Pathogenic Human Tubercle Bacilli

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Abstract
Pathogenic human tubercle bacilli treated with a mold product, mycocidin, in vitro, were completely inhibited in growth when exposed to as little as 0.125 M-units per ml. The M-unit was that amt. of the mold extract per ml. of Long''s synthetic medium which completely inhibited the growth of a standard inoculum (a 5-day-old pellicle of the non-pathogenic strain of M. tuberculosis var. hominis on Long''s medium). When the bacilli in suspension were exposed for 3, 5 or 7 days to 1 or 2 M-units per ml. and were injd. into guinea pigs, the animals failed to develop tuberculosis.

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