Bioactivation of CB 1954: Reaction of the active 4-hydroxylamino derivative with thioesters to form the ultimate DNA-DNA interstrand crosslinking species
- 9 October 1991
- journal article
- Published by Elsevier in Biochemical Pharmacology
- Vol. 42 (9) , 1691-1697
- https://doi.org/10.1016/0006-2952(91)90503-w
Abstract
No abstract availableKeywords
This publication has 11 references indexed in Scilit:
- The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)Biochemical Pharmacology, 1991
- The nitroreductase enzyme in walker cells that activates 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to 5-(aziridin-1-YL)-4-hydroxylamino-2-nitrobenzamide is a form of NAD(P)H dehydrogenase (quinone) (EC 1.6.99.2)Biochemical Pharmacology, 1988
- A new cytotoxic, DNA interstrand crosslinking agent, 5-(aziridin-1-yl)-4-hydroxylamino-2-nitrobenzamide, is formed from 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) by a nitroreductase enzyme in walker carcinoma cellsBiochemical Pharmacology, 1988
- Quantitative estimation of cisplatin-induced DNA interstrand cross-links and their repair in mammalian cells: Relationship to toxicityPharmacology & Therapeutics, 1987
- CB 1954 revisitedCancer Chemotherapy and Pharmacology, 1986
- CB 1954 revisitedCancer Chemotherapy and Pharmacology, 1986
- The binding of N-hydroxy-2-acetylaminofluorene to DNA and repair of the adducts in primary rat hepatocyte culturesCarcinogenesis: Integrative Cancer Research, 1981
- The metabolism of the anti-tumour agent 5-(1-aziridinyl)-2,4-dinitrobenzamide (CB 1954)Biochemical Pharmacology, 1976
- Seryl-tRNA synthetase and activation of the carcinogen 4-nitroquinoline 1-oxideNature, 1975
- 2,4-Dinitro-5-ethyleneiminobenzamide (CB 1954): A potent and selective inhibitor of the growth of the Walker carcinoma 256Biochemical Pharmacology, 1969