Sequestration of free cholesterol in cell membranes by prions correlates with cytoplasmic phospholipase A2activation
Open Access
- 12 February 2008
- journal article
- Published by Springer Nature in BMC Biology
- Vol. 6 (1) , 8
- https://doi.org/10.1186/1741-7007-6-8
Abstract
The transmissible spongiform encephalopathies (TSEs), otherwise known as the prion diseases, occur following the conversion of the normal cellular prion protein (PrPC) to an alternatively folded isoform (PrPSc). The accumulation of PrPSc within the brain leads to neurodegeneration through an unidentified mechanism. Since many neurodegenerative disorders including prion, Parkinson's and Alzheimer's diseases may be modified by cholesterol synthesis inhibitors, the effects of prion infection on the cholesterol balance within neuronal cells were examined.Keywords
This publication has 38 references indexed in Scilit:
- Higher-order organization and regulation of adenylyl cyclasesTrends in Pharmacological Sciences, 2006
- Simvastatin prolongs survival times in prion infections of the central nervous systemBiochemical and Biophysical Research Communications, 2006
- Increased Src kinase level results in increased protein tyrosine phosphorylation in scrapie‐infected neuronal cell linesFEBS Letters, 2006
- Inhibitors of the Mitogen-Activated Protein Kinase Kinase 1/2 Signaling Pathway Clear Prion-Infected Cells from PrPScJournal of Neuroscience, 2005
- Phospholipase A2 Inhibitors or Platelet-activating Factor Antagonists Prevent Prion ReplicationJournal of Biological Chemistry, 2004
- The role of platelet activating factor in prion and amyloid-β neurotoxicityNeuroReport, 2004
- Binding of neural cell adhesion molecules (N-CAMs) to the cellular prion proteinJournal of Molecular Biology, 2001
- Association of p75 with Caveolin and Localization of Neurotrophin-induced Sphingomyelin Hydrolysis to CaveolaeJournal of Biological Chemistry, 1997
- Calcium-sensitive Transcriptional Activation of the Proximal CCAAT Regulatory Element of the grp78/BiP Promoter by the Human Nuclear Factor CBF/NF-YPublished by Elsevier ,1996
- Cholesterol controls the clustering of the glycophospholipid-anchored membrane receptor for 5-methyltetrahydrofolate.The Journal of cell biology, 1990