Maintenance of heterochromatin by RNA interference of tandem repeats
- 30 October 2003
- journal article
- Published by Springer Nature in Nature Genetics
- Vol. 35 (3) , 213-214
- https://doi.org/10.1038/ng1252
Abstract
Tandem repeats are prone to epigenetic silencing regulated by RNA interference. This may be because siRNAs from tandem array transcripts are regenerated by RNA-dependent RNA polymerase (RdRP) and Dicer, but siRNAs from single-copy sequences are exhausted by sequential use of downstream primers by RdRP. This could account for the formation of heterochromatin from tandem repeats.Keywords
This publication has 18 references indexed in Scilit:
- Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAiScience, 2002
- 15 Repeat-induced gene silencing in fungiAdvances in Genetics, 2002
- On the Role of RNA Amplification in dsRNA-Triggered Gene SilencingCell, 2001
- RNA: Guiding Gene SilencingScience, 2001
- Arabidopsis SGS2 and SGS3 Genes Are Required for Posttranscriptional Gene Silencing and Natural Virus ResistanceCell, 2000
- A genetic link between co-suppression and RNA interference in C. elegansNature, 2000
- Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymeraseNature, 1999
- Expansions of transgene repeats cause heterochromatin formation and gene silencing in DrosophilaCell, 1994
- CHROMOSOME ORGANIZATION AND GENIC EXPRESSIONCold Spring Harbor Symposia on Quantitative Biology, 1951
- Structure of HeterochromatinNature, 1944