Ultrastructural Lesions of Pyridoxine Toxicity in Beagle Dogs
Open Access
- 1 November 1981
- journal article
- research article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 18 (6) , 769-777
- https://doi.org/10.1177/030098588101800607
Abstract
Three adult Beagle dogs given pyridoxine hydrochloride orally at a dose of 150 mg/kg body weight/day for about 100 days developed ataxia and had spastic, dysmetric leg movements. Ultrastructural alterations in the dorsal funiculus of the spinal cord were degeneration and loss of axons and myelin, and secondary changes of the myelin sheaths. Possible pathogenic mechanisms of pyridoxine neurotoxicity are discussed.Keywords
This publication has 16 references indexed in Scilit:
- The Subacute Neurotoxicity of Excess Pyridoxine HCl and Clioquinol (5-Chloro-7-Iodo-8-Hydroxyquinoline) in Beagle Dogs. II. PathologyVeterinary Pathology, 1981
- Subacute toxicity of pyridoxine hydrochloride in the beagle dogToxicology and Applied Pharmacology, 1978
- VITAMIN B6 TRANSPORT IN THE CENTRAL NERVOUS SYSTEM: IN VIVO STUDIESJournal of Neurochemistry, 1978
- VITAMIN B6 TRANSPORT IN THE CENTRAL NERVOUS SYSTEM: IN VITRO STUDIESJournal of Neurochemistry, 1978
- Effect of pyridoxal administration on the contents of pyridoxal phosphate and .GAMMA.-aminobutyric acid in mouse brain.Journal of Nutritional Science and Vitaminology, 1978
- Regulation of pyridoxal 5′-phosphate metabolism in liverBiochemical and Biophysical Research Communications, 1974
- The Pathology of the Central Myelinated AxonPublished by Elsevier ,1972
- Deficiency Effects in AnimalsPublished by Elsevier ,1968
- PYRIDOXINE (VITAMIN B6)Published by Elsevier ,1966
- Toxicity of Vitamin B6Experimental Biology and Medicine, 1940