FURTHER STUDIES ON INCREASED SUSCEPTIBILITY TO CHLOROFORM POISONING PRODUCED IN THE ALBINO RAT BY INJECTION OF CRYSTALLINE THYROXIN

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Abstract
Three sets of expts. are discussed. 2 were undertaken in order to determine whether the low glycogen content of the liver during hyperthyroidism is responsible for the increased susceptibility to chloroform poisoning shown by thyroxin-fed rats. In the first set of expts., an attempt was made to maintain a normal liver glycogen content in thyroxin-treated rats. Their increased susceptibility to chloroform poisoning was not diminished by the higher level of liver glycogen. Following this, the liver glycogen of normal rats was reduced by starvation, and the susceptibility of this group compared with that of the thyroxin-fed rats. The results of these 2 sets of expts. did not support the view that the increased susceptibility was due simply to lowered liver glycogen. In a 3d set of expts. a high protein diet did not afford protection to the thyroxin-fed rats against chloroform poisoning.