TESTICULAR SIZE AND SHAPE OF 47,XYY AND 47,XXY MEN IN A DOUBLE-BLIND, DOUBLE-MATCHED POPULATION SURVEY

  • 1 January 1979
    • journal article
    • research article
    • Vol. 31  (6) , 697-703
Abstract
The testicular size and shape of 12 men with 47,XYY, 14 men with 47,XXY and 52 matched controls with 46,XY are reported. The abnormal karyotypes were identified in a systematic population search for XYY and XXY men. The subjects and their matched controls were examined in a double-blind fashion. The testes of the XYY men showed no significant differences from those of their XY controls for volume or shape. Previous reports of abnormal testes in XYY individuals reflect selection and publication bias and do not provide an accurate description of the condition of 47,XYY men''s testicles. As expected, the testes of the XXY men were significantly smaller than those of their XY controls, and there was also a difference in shape. The mean size in this sample of XXY was larger than in previous reports on Klinefelter syndrome patients, indicating that previous reports on XXY identified in clinics for male hypogonadism and other institutions, also suffered from selection bias.