In vitro evaluation of CENTA, a new beta-lactamase-susceptible chromogenic cephalosporin reagent

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Abstract
CENTA is a newly synthesized, .beta.-lactamase-labile, chromogenic cephalosporin reagent which changes color from light yellow to chrome yellow concomitant with hydrolysis of the .beta.-lactam ring. This compound offers promise as a diagnostic reagent comparable to other chromogens (PADAC and nitrocefin) for the early detection of .beta.-lactamase-producing clinical isolates, while retaining some antimicrobial effect against Escherichia coli, Klebsiella spp., Proteus mirabilis, Staphylococcus aureus and non-enterococcal Streptococcus spp. CENTA is relatively unaffected by commonly used microbiological media and human serum.