HLA Antigen (A & B Loci) Frequency in Addisonian Pernicious Anaemia

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Abstract
Patients (66) with Addisonian pernicious anemia were HL-A typed and compared with 86 controls of the same ethnic group. No deviation in antigen frequency specific for the disease group as a whole. The most significant deviation found was an increased frequency of HLA-B8 in those patients with coincident thyroid autoantibodies. Pernicious anemia seems to be the exception to the demonstrated association between HLA-B8 and the organ specific autoimmune diseases studied up to the present time.