Effect of Biotin on Fatty Acid Distribution in Escherichia coli

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Abstract
Biotin deficiency causes changes in the composition and distribution of the fatty-acids in cell wall-cell membrane fractions of E. coli T 94A. Most notable among the fatty-acid changes are decreased amounts of unsaturated fatty-acids, the presence of un-saponifiable lipid material and the lack of a lipopolysaccharide fraction in the cell wall-cell membrane. Also, though the hexane-extractable material from the lipoprotein fraction of biotin-adequate cells will transfer glucose from water to hexane, the same material from biotin-deficient cells will not.