DNA methylation of viruses infecting a eukaryoticChlorella-like green alga
Open Access
- 1 January 1985
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 13 (10) , 3471-3478
- https://doi.org/10.1093/nar/13.10.3471
Abstract
The genomic DNAs of the eukaryotic Chlorella-like green alga, strain NC64A, and eleven of its viruses all contain significant levels of 5-methyldeoxycytidine. In addition, the host DNA as well as six of the viral DNAs also contain N6-methyldeoxyadenosine. At least some of the methylated bases in the host reside in different base sequences than the nethylated bases in the viruses as shown by differential susceptibility to restriction endonuclease enzymes. This suggests that the viruses encode for DNA methyltransferases with sequence specificities different from that of the host enzyme.Keywords
This publication has 17 references indexed in Scilit:
- The effect of site specific methylation on restriction endonuclease cleavage (update)Nucleic Acids Research, 1983
- DNA Methylation--A Regulatory Signal in Eukaryotic Gene ExpressionJournal of General Virology, 1981
- Frog virus 3 DNA is heavily methylated at CpG sequencesVirology, 1980
- Molecular Cloning, Refined Physical Map and Heterogeneity of Methylation Sites of Papilloma Virus Type 1a DNAEuropean Journal of Biochemistry, 1980
- Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate.Proceedings of the National Academy of Sciences, 1979
- Comparative study of DNA methylation in three unicellular eucaryotesJournal of Bacteriology, 1978
- Hydroxymethyluracil in Eukaryote DNA: A Natural Feature of the Pyrrophyta (Dinoflagellates)Science, 1976
- Methylated bases in DNA from Paramecium aureliaBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
- [6N]METHYL ADENINE IN THE NUCLEAR DNA OF A EUCARYOTE, TETRAHYMENA PYRIFORMIS The Journal of cell biology, 1973
- [The presence of 5-methylcytosine and 6-methylaminopurine in the composition of DNA in some algae].1968