Industrial transformations of penicillins and cephalosporins
- 1 January 1993
- journal article
- review article
- Published by Wiley in Recueil des Travaux Chimiques des Pays-Bas
- Vol. 112 (2) , 66-81
- https://doi.org/10.1002/recl.19931120203
Abstract
A survey is presented of transformations of penicillin G into penicillin and cephalosporin derivatives. Amongst other things the issues discussed are the conversion of penicillin G into 6‐aminopenicillanic acid (6‐APA) and some semi‐synthetic penicillins, ring expansion of the penicillin nucleus giving the cephalosporin nucleus and subsequently 7‐aminodeacetoxycephalosporanic acid (7‐ADCA), and the synthesis of various 3′‐substituted cephalosporin derivatives, including the tert‐butyl ester of 3‐(bromomethyl)‐7‐(phenylacetamido)‐3‐cephem 1‐oxide (3‐BMC®).Keywords
This publication has 23 references indexed in Scilit:
- An efficient nonenzymatic conversion of benzylpenicillin to 6‐aminopenicillanic acidRecueil des Travaux Chimiques des Pays-Bas, 1970
- Chemistry of cephalosporin antibiotics. XIV. Reaction of cephalosporin C with nitrosyl ChlorideJournal of the American Chemical Society, 1969
- The chemistry of penicillanic acids. Part I. 6,6-Dibromo- and 6,6-di-iodo-derivativesJournal of the Chemical Society C: Organic, 1969
- Modifikationen von Antibiotika. 2. Mitteilung [1]. Über die Darstellung von 7‐Amino‐cephalosporansäureHelvetica Chimica Acta, 1968
- Chemistry of Cephalosporin Antibiotics. III. Chemical Correlation of Penicillin and Cephalosporin AntibioticsJournal of the American Chemical Society, 1963
- Chemistry of Cephalosporin Antibiotics. I. 7-Aminocephalosporanic Acid from Cephalosporin CJournal of the American Chemical Society, 1962
- ENZYMATIC HYDROLYSIS OF THE SIDE CHAIN OF PENICILLINSJournal of the American Chemical Society, 1960
- Bacterial Penicillin AmidaseNature, 1960
- Cephalosporin C, a New Antibiotic containing Sulphur and D-α-Aminoadipic AcidNature, 1955
- FORMATION OF THE ISONICOTINIC ACID HYDRAZIDE ANALOG OF DPN1Journal of the American Chemical Society, 1953