A SENSITIVE METHOD FOR THE ASSAY OF ANDROGENS BASED ON THEIR POWER TO ALTER THE REACTIONS OF THE MOUSE KIDNEY TO CHLOROFORM

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Abstract
SUMMARY: Susceptibility to necrosis of the renal tubules after the inhalation of small concentrations of chloroform vapour was induced in castrated mice by a total dose of 10μg of testosterone propionate. With increasing doses of androgen greater amounts of damage to the renal tubules resulted from the same exposures to chloroform. A simple method for the measurement of the degree of damage in the kidney enabled a dose-response curve to be constructed. These findings appear to provide the basis of a sensitive method for the detection and assay of androgens.