Postoperative Massive Liver Necrosis

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Abstract
MASSIVE liver necrosis is a rare entity, having an autopsy incidence of 0.15 per cent.1 It has been attributed to such conditions as viral hepatitis,2 drug hepatitis,1 carbon tetrachloride and chloroform poisoning3 and shock3 , 4 or associated administration of pressors.5 Interest in this disease has been rekindled by the recent spate of reports relating massive liver necrosis to halothane anesthesia.6 7 8 9 10 11 12 13 14 15 16 17 18 19 These reports have led to a comprehensive investigation, the National Halothane Study, which is currently being carried out under the auspices of the National Academy of Sciences–National Research Council to establish whether halothane is a cause of massive liver necrosis or . . .