THE PATHOGENESIS OF COXSACKIE GROUP B VIRUSES IN EXPERIMENTAL INFECTION

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Abstract
The experimental findings show that in mouse-adapted strains of different Coxsackie group B types of virus, distinctly varied patterns of pathogenesis exist. In the particular host population under study, both of the B-3 strains examined are peculiarly cardiotropic for 17-day-old mice and adult mice. In contrast, the B-1 strain, while mildly cardiotropic for sucklings, neither propagates nor produces lesions in the 17-day weanlings. The age factor does not seem to have any effect upon two strains of B-5 viruses which show the same degree of moderate cardiotropism in sucklings and weanlings.It can be seen from observations made upon the brown fat that lesions are produced in adult mice with all but B-2 virus. Interpretation of the heart lesion, however, is complicated by the appearance of heart lesions in control animals of this age. These heart lesions were not observed in the control sucklings or weanlings. In spite of this, there is evidence that the B-3 virus induces specific heart lesions in adult mice.It would appear that the B-2, B-4, and the Kita strain of B-5 provoke a marked inflammatory cell response in the brain which distinguishes them from the other strains.