Induction of Chromosome Aberrations by 4·9 MeV Protons in Human Lymphocytes

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Abstract
The dose–response relationship and distribution of chromosome aberrations between cells was studied in G0 human peripheral blood lymphocytes following in vitro exposure to 4·9 MeV protons. The dose–response relationship of dicentric yield showed a significant dose–quadratic component and was best expressed by 2·76 × 10−1 D + 1·36 × 10−1 D2 (D in Gy). The distribution of dicentrics between cells was over-dispersed compared with a Poisson distribution. Analysis of the data indicated that the over-dispersion was caused by a spatial limitation in the interaction between tracks. The interaction distance was estimated to be around 0·2 µm.