Kanic acid alters cholinergic responses in the rat retina: A 2-deoxyglucose study

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Abstract
Intraocular injections of the neuroexcitatory toxin, kainic acid, did not alter the output of the retinal ganglion cells, as determined by the rate of glucose use in the stratum griseum superficialis of the superior colliculus. However, significant differences were observed in cholinergic interactions of the ganglion cells after kainic acid treatment. Intraocular injection of kainic acid prevented the increase in the stratum griseum superficialis activity typically produced by systemic injection of the acetylcholinesterase inhibitor diisopropylfluorophosphate (DFP). In addition, the retinal ganglion cells were strikingly sensitive to intraocular injections of acetylcholine 1 week after exposure to kainic acid, reflected in the marked increased glucose utilization in the stratum griseum superficialis. This responsiveness to acetylcholine may be entirely due to the 80% decrease in acetylcholinesterase in the retina observed 1 week after kainic acid exposure or in part to a supersensitivity of the ganglion cells following the period of acetylcholine depletion.