Effect of Adrenalectomy on Pressor Responsiveness to Angiotonin and Renin

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Abstract
Pressor response to injection of renin is reduced or abolished during adrenal insufficiency without concurrent change in response to angiotonin and other drugs. Selective loss of response to renin is considered to result from depletion of available renin-substrate by endogenous renin; when release of endogenous renin is precluded by nephrectomy, adrenalectomy does not cause diminution of response to renin. The increase in response to angiotonin and renin that follows nephrectomy is not prevented by adrenalectomy.