ADENOSINE A2 RECEPTORS ON HUMAN-MONOCYTES MODULATE C2 PRODUCTION
- 1 January 1984
- journal article
- research article
- Vol. 57 (2) , 454-460
Abstract
Adenosine inhibits [complement component] C2 production by human monocytes. The use of synthetic analogs of adenosine suggested that the action was mediated by receptors of A2 type. EHNA [erythro-9-(2-hydroxy-3-nonyl)-adenine] which inhibits the enzyme adenosine deaminase and increases the concentration of intracellular adenosine also reduces C2 production. It is, therefore, possible that endogenous adenosine regulates C2 synthesis.This publication has 17 references indexed in Scilit:
- Cyclic AMP-Mediated Modulation of the Production of the Second Component of Human Complement by MonocytesInternational Archives of Allergy and Immunology, 1981
- Adenosine receptors and the regulation of adenylate cyclase.1981
- Modulation of cyclic AMP metabolism by S-adenosylhomocysteine and S-3-deazaadenosylhomocysteine in mouse lymphocytes.Proceedings of the National Academy of Sciences, 1980
- Improved microfluorometric DNA determination in biological material using 33258 HoechstAnalytical Biochemistry, 1979
- Adenosine analogs inhibit adipocyte adenylate cyclase by a GTP-dependent process: basis for actions of adenosine and methylxanthines on cyclic AMP production and lipolysis.Proceedings of the National Academy of Sciences, 1978
- The control of the metabolism and the hormonal role of adenosine.1978
- Two distinct adenosine-sensitive sites on adenylate cyclase.Proceedings of the National Academy of Sciences, 1977
- CORONARY DILATORY ACTION OF ADENOSINE-ANALOGS - COMPARATIVE-STUDY1977
- A role for adenosine deaminase in human monocyte maturation.Journal of Clinical Investigation, 1976
- The physiological activity of adenine compounds with especial reference to their action upon the mammalian heart1The Journal of Physiology, 1929