LIGHT CHAIN DIVERSITY OF MURINE ANTI-STREPTOCOCCAL ANTIBODIES - IGCH-LINKED EFFECTS ON L-CHAIN EXPRESSION

  • 1 January 1978
    • journal article
    • research article
    • Vol. 121  (1) , 149-158
Abstract
L chains derived from anti-group A streptococcal carbohydrate antibodies [anti-GAC] raised in A/J, BALB/cJ, C57BL/6J, CB-20, BAB-14 and CAL-20 mice were examined by isoelectric focusing. Multiple strain-associated differences in the degree and frequency of expression of particular L chain spectrotypes were observed. Analysis of L chain-focusing patterns in allotype-congenic mice revealed that IgCH[immunoglobulin constant region, heavy chain]-linked genes can have profound effects on the L chain phenotypes expressed by strains with identical L chain genotypes. The overall spectrotypic diversity of L chains from anti-GAC antibodies appears to be less extensive than the diversity of the antibodies from which these L chains derive, documented by similar techniques. These results are interpreted in light of the significance of combinatorial diversity in generating antibody heterogeneity.

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