TRANSPLANTATION STUDIES OF STRONG AND WEAK HISTOCOMPATIBILITY BARRIERS IN MICE. I. IMMUNIZATION

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Abstract
Using coisogenic strains of mice differing by strong or weak, or strong-plus-weak histocompatibility factors, a study was made of the induction and duration of immunity. Immunization with spleen cells in the presence of only an H-2 incompatibility was rapid in onset but of short duration, while immunization across the weaker, H-3 barrier was slow in onset and of longer duration. When strong and weak factors were combined, immunity was of shorter duration than when only the strong factor was involved. The long-term immunity that normally results from skin grafting was found to be abolished if the recipient was preimmunized with lymphoid cells. Removal of the regional nodes early in the development of immunity following skin grafting prevented permanent immunity.