High molecular weight opioid-containing proteins in striatum.
- 1 August 1978
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 75 (8) , 4021-4023
- https://doi.org/10.1073/pnas.75.8.4021
Abstract
Striatal extracts of guinea pigs, rats, and cattle contained 2 large proteins (> 40,000 and > 100,000 daltons) that on treatment with trypsin yield opioid peptides differing chromatographically from the opioid nonapeptide generated by trypsin digestion of endorphins, .beta.-lipotropin or pro-opiocortin. The large opioid proteins found in the pituitary do not appear to be present in the striatum. The striatal enkephalins may be produced via a pathway that differs from the 1 deduced from studies on the pituitary.This publication has 11 references indexed in Scilit:
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