HUMAN CYTOMEGALOVIRUS INFECTION: ELECTRON AND LIGHT MICROSCOPIC OBSERVATIONS OF THE PAROTID GLANDS OF AN AUTOPSY CASE

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Abstract
HCMV infection in the parotid gland removed at autopsy from a 5‐month‐old male infant with generalized cytomegalic inclusion disease was investigated electron‐ and light‐ microscopically, and virus invasion, synthesis and release in the host cell were described and compared with the results of in vivo experiments previously reported.In the infected nucleus several types of inclusions were formed, and a virus‐synthesizing matrix was seen to produce numerous developmental forms of the virus, usually with, but infrequently without, a variable core. Three unusual structures were seen in the nucleus of cytomegalic inclusion cells! tortuous strings, bamboo‐like virus‐synthesizing bodies and intranuclear sacs containing vesicles. The coat of mature HCMV in the cytoplasm appeared to be a triple‐layered structure. The release of viruses into the parotid glandular lumen occurred by emiocytosis.