RENAL-TRANSPLANTATION IN ALPORTS-SYNDROME - ANTI-GLOMERULAR BASEMENT-MEMBRANE GLOMERULONEPHRITIS IN THE ALLOGRAFT
- 1 January 1982
- journal article
- research article
- Vol. 57 (1) , 35-43
Abstract
Eleven patients with Alport''s syndrome had renal transplantation between 1963 and 1980. The mean follow-up is 6 yr (6 mo. to 14 yr). All 11 patients are currently alive. Ten have funcitoning grafts, and in 9 the serum creatinine concentration is < 2 mg/dl. Three patients received a 2nd allograft. Histologic study of the allografts that were lost revealed a diffuse crescentic glomerulonephritis with strongly positive linear IgG staining of the glomerular basement membrane in the allografts of 2 of the 3 patients; circulating antiglomerular basement membrane antibodies were present in 1 patient. These 2 patients had successful retransplantation and they remain well 1.5 and 4.5 yr later. Renal transplantation in patients with Alport''s syndrome is a worthwhile and very satisfactory procedure.This publication has 10 references indexed in Scilit:
- VARIABILITY OF ANTI-GBM BINDING IN HEREDITARY NEPHRITIS1981
- Early Pathologic Features of Hereditary Nephritis: A Clinicopathologic CorrelationPathology - Research and Practice, 1980
- Chronic hereditary nephritisHuman Pathology, 1979
- Hereditary Nephritis: A Re-examination of its Clinical and Genetic FeaturesAnnals of Internal Medicine, 1978
- Nephritogenic immunopathologic mechanisms and human renal transplants: The problem of recurrent glomerulonephritisKidney International, 1976
- SPECIFICITY OF SPLIT RENAL MEMBRANES IN HEREDITARY NEPHRITIS1976
- RENAL PATHOLOGY IN HEREDITARY NEPHRITIS WITH NERVE DEAFNESS1966
- Hereditary Nephropathy and Loss of HearingJAMA Otolaryngology–Head & Neck Surgery, 1965
- Hereditary nephropathy, deafness and renal foam cellsThe American Journal of Medicine, 1961
- GENETIC STUDY OF HEREDITARY RENAL DYSFUNCTION WITH ASSOCIATED NERVE DEAFNESS1961