PAIRED HELICAL FILAMENTS IN RAT SPINAL GANGLIA FOLLOWING CHRONIC ALCOHOL ADMINISTRATION: AN ELECTRON MICROSCOPIC INVESTIGATION*

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Abstract
Volk B. 1980Neuropathology and Applied Neurobiology6, 143–153Paired helical filaments in rat spinal ganglia following chronic alcohol administration: an electron microscopic investigationYouang Wistar rats were given a 15% (v/v) ethanol solutionad libitumfor at least 6 months, spinal ganglia (C6–7 and Ll‐2) in some of the experimental animals showed paired helical filaments. These curvilinear profiles consisted of 10 nm filaments with the twist every 35nm. There was also an increase in granular material and in nematosomes. Whether these features may be caused by an impaired cerebral protein biosynthesis is discussed.