Induction of Prolonged Latency in Psittacosis Infected Cells by Aminopterin.

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Abstract
Psittacosis virus was sensitive to aminopterin during the early stages of replication in tissue cultured cells. After hour 20 of virus infection, a factor appeared in the infected cells which reversed the effect of aminopterin on virus. Folinic acid reversed the inhibitory effect of aminopterin on virus and cells. Psittacosis virus, inhibited in tissue culture cells by medium containing aminopterin, remained latent for at least 4 weeks, and resumed replication after addition of folinic acid to the culture medium.