Anti-histamine effect of sodium salicylate and its bearing upon the skin-diffusing activity of hyaluronidase

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Abstract
Hyaluronidase from bull semen had no significant effect on the capillary permeability of rabbits and its spreading action was not affected by salicylate. Histamine increased the spreading action of hyaluronidase additively. Snake venom had a spreading action and a marked capillary-damaging effect. The latter was inhibited by salicylate. Salicylate inhibited the capillary-damaging action of histamine and reduced the spreading action of hyalur-onidase-histamine to that of the enzyme alone.