Beneficial Effects of Ibuprofen in Acute Myocardial Ischemia

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Abstract
Ibuprofen a nonsteroidal anti-inflammatory agent was studied in the early stages of myocardial ischemia to determine if it helps preserve myocardial integrity. Ibuprofen was administered i.v. to cats at a dose of 12.5 mg/kg at the time of coronary artery occlusion and again 2.5 h later. Ibuprofen significantly prevented the loss of myocardial creatine phosphokinase (CPK) release in ischemic cardiac tissue, returned S-T segment elevation toward normal values and prevented the myocardial loss of compounds having free amino N groups, an index of proteolysis. Ibuprofen moderated the increased plasma CPK activity but plasma CPK values 5 h after coronary occlusion were above control values. Ibuprofen significantly prevented alterations in 3 of the 4 indices used to assess myocardial ischemic damage. The protective mechanism of ibuprofen may be via stabilization of cellular membranes (i.e., lysosomal membranes) and to a lesser extent on reduction in myocardial O2 demand.